A Distributed Information Services Architecture to Support Biomarker Discovery in Early Detection of Cancer

Informatics in biomedicine is becoming more and more interconnected with distributed information services, interdisciplinary correlation, and cross-institutional collaboration. Partnering with NASA, the Early Detection Research Network, a program managed by the National Cancer Institute, has been defining and building emerging informatics architecture to support the discovery of biomarkers in their earliest stages. The architecture established by the informatics teams working with the National Cancer Institute and the Early Detection Research Network serves a blueprint for constructing a set of services focused on the capture, processing, management and distribution of information through the phases of biomarker discovery and validation. This focus of this paper will be to define the architecture, the associated services, the overall information model and framework for which these services can be integrated to form a knowledge grid for the scientific community. This paper was submitted to eScience 2006.